VAZOIFI SIDODII ORGANIZM

VAZOIFI SIDODII ORGANIZM, vazoifi baryerii organizm, faoliyati muhofizi, ki tavassuti mekhanizmhoi makhsusi fiziologi (hoilho) ijro karda meshavand. Hoilho organizmro az tasiroti nomusoidi muhit hifz namuda, bahri ba on vorid shudani bakteriyaho, virusho va moddahoi zararnok mone megardand, baroi doimi nigoh doshtani tarkibu khosiyati khun, limfa, moei bofta musoidat mekunand.
Hoil (baryer)-ho shartan beruni va daruni meshavand. Ba hoilhoi beruni pust, uzvhoi nafaskashi, uzvhoi hozima, az jumla jigar, gurda mansuband. Pust organizmro az tasiri tagyiroti muhiti zist hifz namuda, dar tanzimi harorat ishtirok mekunad. Hoili pust ba vorid shudani bakteriya va zahrho ba organizm mone meshavad, ba ikhroji mahsuli mubodilai moddaho, mas., ba tavassuti araq, musoidat mekunad (nig. Araqshori). Dar uzvhoi nafaskashi gayr az mubodilai gaz (nig. Nafaskashi) havo az gardu chang va moddahi zararnok (bo yorii pardae, ki javfi bini va naychahoi shushro faro giriftaast) toza karda meshavad. Gizo dar medayu ruda digargun va baroi hazm muvofiq megardad; mahsuloti nosolimi hozima, inchunin bode, ki dar ruda hosil shudaast, az organizm ikhroj meshavand. Jigar vazifai muhimi sidodiro ijro mekunad: payvasthoi zahrnokero, ki az khurok yo dar ruda hosil shuda, ba khun guzashtaand, bezarar megardonad. Gurdaho tarkibi khunro tanzim va onro az mahsuli nihoii mubodilai moddaho toza mekunand. Luobpardahoi javfi dahon, chashm, uzvhoi tanosul niz ba hoilhoi beruni mansuband.
Hoilhoi darunie, ki bayni khunu boftaho voqeand, «hoilhoi gistogemavi» nom dorand. Devorai muyraghoi khun vazifai hoili asosiro ba jo meorad. Boftai payvandi, tashkilahoi limfavi va baze hujayrahoi makhsusi uzvu boftaho niz vazifai muhofizatro ijro mekunand. Bayni khun va sistemai asabhoi markazi (ba istiloh «hoili gematoensefali»), bayni khun va boftahoi chashm (hoili gematooftalmi), bayni khun va gadudhoi tanosul tashkilahoi makhsusi hoil mavjudand. Vazifai khele muhim – hifzi janin (nig. Homilagi) ba hoili hamrohak, ki bayni organizmi modar va janin voqe ast, taaluq dorad. Hamchunin parda va tashkilahoi dokhili hujayra, ki az gishoi murakkabi seqabata iborat buda, baroi hifzi unsurhoi muhimi hujayra peshbini shudaand, vazifai hoilro bajo meorand.
Hoilhoi darunii gistogemavii uzv vazi faoliyat va qobiliyati ba tasiroti zararnok muqobilat kardani onro muayyan mesozand. Onho saddi az khun ba bofta intiqol yoftani moddahoi begona (vazifai muhofizat) shuda, tarkib va khosiyati muhiti gizoii uzvro tanzim menamoyand (baroi faoliyati on sharoiti musoid faroham meorand). CHunonchi, hangomi khele ziyod gashtani gilzati in yo on modda dar khun miqdori on dar boftahoi uzv mumkin ast tagyir nayobad yo andake ziyod shavad. Baraks, miqdori moddae, ki baroi boftahoi uzv zarur ast, sarfi nazar az doimi yo hatto past budani gilzati on, dar khun meafzoyad. Hoilho az khun moddahoi baroi uzvu boftaho zaruriro girifta, az onho mahsuli mubodilaro ikhroj mekunand.
Ravandhoi fiziologii organizmi solim yo bemor, tanzimi faoliyat va tagziyai uzv, tasiri mutaqobilai bayni uzvhoi judogonai organizmi tom ba vazi hoilhoi gistogemavi aloqamand meboshand. Ahamiyati hoilho khususan dar hifzi organizm az tasiroti angezandai bemorihoi gunogun va zahri onho khele kalon ast. Bakteriyaho, virusho va moddahoi zahrnok bo khun davr zada, dar bisyor holatho metavonand mujibi paydoishi bemori gardand. Sababi in bisyor vaqt ba zafi muqobilati hoilho vobasta ast. Dar ayni hol tabobati manbai bemori binobar purzur shudani muqobilati hoili uzvi mariz nisbat ba in yo on doru dushvor megardad.
Hoilhoi gistogemavi ba tarkibu khosiyathoi muhiti dokhilii organizm mutobiq megardand. In bahri doimi nigoh doshtani khosiyathoi fiziologi va biokhimiyavi, hifzi salomati, peshgirii bemoriho ahamiyati kalon dorad.
Vazi hoilhoi gistogemavi vobasta ba sinnu sol, tasiri asab va gormonho, hangomi tahayyuj va bozdorii tashkilahoi asab, az tasiri bekhobi, gurusnagi, narkoz, dar asnoi baze amroz va mayzadagi tagyir meyobad. Bazan bo maqsadi muolijavi muqobilati hoilhoro ba tavri suni ziyod yo kam mekunand. Baroi in ba khun doruhoi khimiyavi meguzaronand, bo nurhoi rentgen, ultrabunafsh, infrasurkh tasir merasonand. Dar asnoi tabobati baze bemorihoi magzi sar doruro bar khilofi hoili gematoensefali bevosita ba moei harommagz ravona mesozand.