MIORELAKSANTHO

MIORELAKSANTHO (Myorelaxantia; az mio… va lot. relaxans, relaxantis – sustiovar, zaifsozanda), doruhoe, ki tonusi mushakhoi skeletro to haddi komilan beharakat gashtani onho sust mekunand. M. vobasta ba tasir du khel – markazi va kanori meshavand. Ba M.-i tasirashon kanori moddahoi kuraremonand mansuband; onho bevosita ba kholinoretseptorhoi mushakhoi skelet tasir rasonda, intiqoli asabi-mushakiro khalaldor mesozand.
Ba M.-i tasirashon markazi doruhoi gunogun, ki dar barobari samarai muolijavi hamchunin markazi tanzimi tonusi mushakhoro taboh menamoyand, dokhil meshavand, mas., trankvilizatorho (sibazon, khlozepid, fenazepam va g.). Midoklam va baklofen niz ba guruhi moddahoi tasirashon markazi mansub meboshand. M.-i tasirashon markazi bar farqi moddahoi kuraremonand ba intiqoli impulsho ba sinapshoi asabu mushaki tasir namerasonand.
Dar amaliyai tib moddahoi kuraremonand bo maqsadi sust kardani tonusi mushakho hangomi amaliyoti jarrohi kor farmuda meshavand. M.-i tasirashon markazi asosan hangomi bemorihoe, ki tonusi mushakhoi skelet baland megardand, ba kor meravand.