METASTAZ

METASTAZ (Metastasis; ba manoi guzarish, joyivazkuni), manbai duyumi bemori, ki dar natijai az manbai yakumi on ba organizm pahn gashtani omili bemoriovar (hujayrahoi omos, angezandai siroyat va g.) paydo meshavad. Vobasta ba tarzi gustarish M.-hoi limfageni va gematogeniro farq mekunand. Az rui tasavvuroti hozira M. gustarish (disseminatsiya)-i hujayrahoi omosi badfarjomro dar nazar dorad. Holathoi ba M. tabdil yoftani omoshoi nekfarjom niz duchor meoyand. Qobiliyati hosil kardani M., yane ba vositai limfa va khun ba organizm pahn gashtan, khosi hujayrahoi solim niz meboshad (mas., hujayrahoi charbi, hujayrahoi khunofari magzi ustukhon va g.). Hususiyati asosii hujayrahoe, ki M. hosil mekunand, dar rushdi onhoro nazorat karda natavonistani organizm ast. Uqdahoi ba M. tabdilyofta tamomi khususiyathoi omosi avvalro, ki az on paydo shudaand, sohib megardand (sokhti mikroskopi, qobiliyati hosil kardani hujayrahoi monand va g.).
Tarzi M.-i gematogeni nisbatan khub tahqiq shudaast (dar shush, jigar, ustukhon va dig. uzvho). M.-i gematogeni chand davrai inkishof dorad: 1) az omosi avvalin kanda shudani hujayra va az devorai rag guzashta ba khun hamroh gashtani on; 2) dar khun gardish kardani hujayrahoi omos; 3) ba devorai rag chaspidan va dar on jo inkishof yoftani hujayrai omos; 4) devorai ragro surokh karda berun omadani massai omosi va dar boftai uzvi zarardida inkishof yoftani M. Mavjudiyati M. dalel ba shakli gustarishi giriftani bemori ast.