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KISLOTAHOI RIBONUKLEAT (KRN)

kislotai-rybonukleatKISLOTAHOI RIBONUKLEAT (KRN), navi kislotahoi nukleat, ki dar tabiati zinda vase pahn shudaand. Az asoshoi purini (adenin, guanin) va piramidini (urasil, sitozin), qandi riboza va boqimondai kislotai fosfat tarkib yoftaand. Beshtar dar sitoplazmai hujayra mavjudand. K. r. dar organizm asosan dar namudi ribonukleoproteidho (RNP) vomekhurand. Rohi biologii KRN az intiqoli akhbori genetiki az genho va ishtirok namudan dar biosintezi safedaho iborat ast. Dar bisyor virushoe, ki kislotai dezoksiribonukleat (KDN) nadorand, KRN noqili moddii akhbori genetiki meboshand. KRN polinukleotidi khattii az dahho va hazorho monomerho – ribonukleotidho tarkibyofta buda, molekulai onho spirali duqabata hosil namekunand. Biosintezi KRN dar yadroi hujayra, dar matritsai KDN bo ishtiroki polimerazaho ba amal meoyad.
Dar hujayrai zindai har yak organizm se namudi KRN mavjud ast: 1) KRN-i ribosomi (KRN-r), ki qarib 80%-i hamai KRN-i hujayrahoro tashkil medihand (onho ba tarkibi hissachahoi sitoplazmavi – ribosomho, ki dar onho biosintezi safedaho ba vuqu meoyand, dokhil meshavand); 2) KRN-i naqliyoti (KRN-n) 15% hamai KRN-i hujayraro tashkil namuda nisbatan bisyor asoshoi gayrimuqarrariro darbar megirand; 3) KRN-i akhbori (KRN-a) kamtar az 5%-i hamai KRN-i hujayraro tashkil medihand; KRN-a dar shakli nuskhai qismhoi muayyani KDN (genho) sintez meshavand va akhboroti az KRN nuskhabardoshtaro ba ribosomaho mebarand.
Dar kafedrai biokhimiyai DDTT ba nomi Abuali ibni Sino vazifai KRN dar mekhanizmi judokunii obi meda va baze bemorihoi jigari odam muqarrar karda shudaast.

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