INGIBITORHO

INGIBITORHO (lot. inhibere – man kardan, nigoh doshtan), moddahoi tabiatashon khimiyavi, ki aksulamalhoi khimiyavi, az jumla biokhimiyaviro sust yo purra qat mekunand. I. dar tib ba sifati doru farovon istifoda megardand. Onho dar sohai tadqiqoti biokhimiyavi niz ba kor meravand. Bisyor I. moddahoi zahrnok mahsub meshavand.
I. faqat ba yak ferment tasir rasonda, jarayoni mubodilai moddahoro purra boz medorad, ki bisyor vaqt oqibati in baroi organizm margovar ast.
I. faoliyati fermenthoro bo du roh – raqobat va gayriraqobat furu menishonand. Dar mavridi tasiri raqobati I. fermentro «fireb» medihand, zero az nigohi khimiyavi ba substrati on khele monand meboshand. Hangomi tasiri gayriraqobati I. bo ferment payvast shuda, sokhtori mollekulahoi onro tagyir medihad, ba hosil gashtani mahsuli reaksiya mone meshavad.
Dar organizmi odamu hayvonot I.-i endogeni hosil meshavand. Onho ravandhoi gunogunro tanzim menamoyand. Mas., atsetilkholin, ki az nugi asabho (hangomi angezishi asabi gumroh) khorij meshavad, ba faoliyati fermenti kholin-atsetiltransferaza tasiri ingibitori merasonad. Dar natija intiqoli junba (impuls)-i asab qat megardad. CHunonchi, sababi asosii az kor bozmondani dil hangomi angezishi asabi gumroh tasiri I. ast. Ba sharofati mavjudiyati ingibitori pepsin (nig. SHirai meda) hujayrahoi gadudi meda az tasiri hazmsozandai fermente, ki khudi on hosil mekunad, hifz karda meshavad. Dar zardobi khuni odam ingibitori fermenti tripsin mavjud ast. Hangomi ba miqdori ziyod ba khun khorij shudani on ingibitori mazkur faoliyati fermentro sust mekunad. Faoliyati mutadili ingibitori tripsin dar zardobi khun ba 300 – 600 millivohid (vobasta ba miqdori fermente, ki tasiri ingibitori rasonda meshavad) barobar ast. Dar mavridi bemorihoi iltihobii gunogun faoliyati ingibitori mazkur dar zardobi khun ba 1500 – 2000 millivohid merasad; hangomi shaklhoi vaznini pankreatit on to 100 – 150 millivohid past mefaroyad.
Dar amaliyai tib doruhoi sershumore istifoda meshavand, ki I.-i fermentho meboshand, mas., I.-i proteinazho (tripsin, kallikrein, plazmin) – pantripin, ingitril, trasilol (kontrikal), gordoks, I.-i kholinesteraza, I.-i monoaminoksidazaho, I.-i karboangidrazaho va g.