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IMMUNOGLOBULINHO

immunoglobulinhoIMMUNOGLOBULINHO (lot. immunis – ozod, az chize khalosshuda va globulus – kura), safedai zardob va tarashshuhi odamu hayvonot, ki misli podtanho buda, dar kori muhofizati organizm az angezandai bemorihoi siroyati shirkat mevarzand.
I. ba 5 guruh judo meshavand. IgG, IgA, IgM, IgD va IgE. Dar tarkibi zardobi khuni odam miqdori IgG taqr. 1,2 g/100 ml ast (70 – 80%-i hamon I.-ro tashkil mekunad). IgA dar zardobi khun va tarashshuhot (obi dahon, falla va g.) dar shakli polimerho vujud dorad. Dar IgM ba muqobili endotoksin (lipopolisakharid)-hoi bakteriyahoi grammusbat va virusho podtanho oshkor karda shudaand. Miqdori IgD va IgE dar zardobi khun kam meboshad. IgE podtanhoe dorad, ki dar aksulamalhoi allergi ishtirok mekunand. Dar mavridi baze bemoriho miqdori I. dar zardobi khun tagyir meyobad (baroi tashkhisi marizi muhim ast).
Juzi asosii doruhoi immunoglobulini IgG meboshad. Baroi peshgirii surkhakon, gepatiti virusii A va dig. bemorihoi siroyati, hamchunin tabobati gipogammaglobulinemiya va agammaglobulinemiya az dorui «Immunoglobulini mutadili odam» (nomi qabliash «Gammaglobulin baroi peshgirii surkhakon») istifoda mekunand. On az mahluli 10%-ai gamma-globulini zardobi khun iborat ast. Voyai muqarrarii on baroi istifoda 1,5 – 3 ml meboshad (faqat ba mushak mefiristand). Bo maqsadi tabobat dorui makhsusi «Immunoglobulini mutadili odam baroi tazriqi dokhilivaridi» istehsol meshavad, ki voyai istifodai on 25 – 50 ml ast.
I.-i makhsus, ki ba muqobili angezandahoi bemorihoi siroyati yo zahri onho podtan dorand, az plazma yo zardobi khuni donorho (bo antigenhoi muvofiq masuniyatnok karda shudaand) hosil karda meshavand. Ba in guna doruho I.-i ziddi kuzoz, stafilokokkho, gripp, ensefalit, surfakabutak va g. mansuband.
Baroi peshgirii bemorii gemolizii navzodho, ki bar asari nomuvofiqii rezusi khuni modaru padar inkishof meyobad, immunoglobulini antirezusi istifoda meshavad. Onro az zardobi khuni odame, ki ba muqobili rezus-antigen podtani ziyod dorad, hosil mekunand. Immunoglobulini antirezusi badi 48 – 72 soati ba dunyo omadani kudak kor farmuda meshavad.

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