BILIRUBIN

BILIRUBIN (az lot. bilis – talkha va ruber – surkh), pigmenti asosii talkha; mahsuli nihoii tajziyai gemoglobin va dig. hosilahoi porfirinho. B. dar natijai silsilai tabaddulotii zayl ba vujud meoyad: gemoglobin → verdoglobin (kholeslobin) → biliverdin → bilirubin. B. ba jigar guzashta, zeri tasiri kislotai glyukuronat konyugat hosil mekunad va hamin tavr, ba B.-i dar ob halshavanda tabdil meyobad. B.-e, ki konyugatsiya nashudaast, dar mavridi tadqiqi biokhimiyavi oshkor nameshavad. Binobar in onro B.-i gayrimustaqim menomand. Baroi oshkor sokhtani konsentratsiyai chunin B. avval onro ba shakli dar ob halshavanda (B.-i mustaqim) tabdil medihand. B. hamrohi talkha ba ruda meguzarad va zeri tasiri mikroflorai on ba sterkobilin va urobilin tabdil meyobad.
Taqriban 70%-i B. dar natijai tajziyai fiziologii eritrositho hosil meshavad; dar 100 ml zardobi khun 0,5 – 1,2 mg (8,5 – 21 mkmol/l) B. mavjud ast, ki seyaki onro B.-i gayrimustaqim tashkil mekunad. Tanosubi mazkur dar mavridi gemolizi barziyod, ikhtiloli guzaronandagii pardai hujayrahoi jigar, iltihobu zahroludii hujayrahoi jigar, ikhtiloli jarayoni mutadili talkha va g. khalal meyobad. B. dar asnoi bemorii gemolizii navzodon dar uzvu bofta va hujayraho gun shuda, miqdori on dar khun va peshob meafzoyad. Hangomi zardparvin konsentratsiyai B.-i umumi dar zardobi khun metavonad ba 20 mg/100 ml rasad (342 mkmol/l). Dar asnoi bemorihoi gemolizii navzodon miqdori B.-i khun az in ham beshtar ast.