ANTIKOAGULYANTHO

ANTIKOAGULYANTHO (Anticoagulantia; az anti… va lot. coagulans – lakhtaband), doruhoe, ki sadi lakhtabandii khun gashta, bo in roh hosil shudani sudda (tromb)-ro peshgiri menamoyand. A. tasiri bevosita va bavosita dorand. Ba A.-i tasirashon bevosita geparin va gidrositrati natriy, ba A.-i tasirashon bavosita neodikumarin, sinkumar, fenilin, amefin mansuband.
A.-ho az rui baze khosiyatho az yakdigar farq dorand. A.-i tasirashon bevosita mustaqiman ba omilhoi lakhtabandi, ki dar khun gardish mekunand, tasir merasonand. Mas., geparin faoliyati tromboplastin, trombin va g.-ro furu menishonad; gidrositrati natriy boshad ionhoi ozodi kalsiyro, ki dar mavridi hosil shudani tromboplastin shirkat mevarzand, payvast menamoyad.
A.-i tasirashon bavosita antagonisthoi vitamini K meboshand (vitamini mazkur hangomi hosil shudani protrombin dar jigar ishtirok mekunad). Onho ba faoliyati omilhoi lakhtabandii khun tasir namerasonand.
Tabobat bo A.-ro dukhtur tain karda, onro zeri nazorat megirad. Orizai khavfnoki muolija bo A. khunravihoi gunogun ast. Dar mavridi rukh namudani nishonahoi khunravi muolijaro qat mekunand.